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This upstream enzyme inhibition approach is mechanistically distinct from precursor supplementation and particularly relevant to metabolically dysfunctional adipose tissue where NNMT overexpression is the primary driver of NAD⁺ deficiency , making 5-Amino-1MQ and NMN/NR complementary rather than equivalent research tools for NAD⁺ biology
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In the Phase 2b trial (2007, n=536) AOD-9604 showed weight reduction only 0.3 kg greater than placebo after 24 weeks
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