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5-HT 2 receptors are located on nerve terminals and cell bodies of dopaminergic neurons in the striatum and the SNc, respectively, and inhibit dopaminergic neuron activities ( 2 receptors relieves 5-HT 2 receptor-mediated inhibition of dopamine release in the striatum and of dopamine neuron firing in the SNc, which leads to alleviation of EPS ( Figure 5 ) ( 2 receptors can reverse various responses of striatal neurons to antipsychotics (D 2 receptor blockade), such as the enhancement of acetylcholine (ACh) release, the increase in metabolic turnover rate of dopamine and the induction of Fos protein expression, in the striatum Figure 5 Serotonergic Modulation of Antipsychotic-Induced EPS As described previously, the serotonergic nervous system plays an important role in modulating EPS induction