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Its ability to stimulate collagen and GAG synthesis at picomolar concentrations, modulate MMP activity for balanced ECM remodeling, and influence gene expression across nearly a third of the human genome places it in a category few peptides occupy

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Szweda, Bertrand Friguet, Age-Dependent Declines in Proteasome Activity in the Heart, Archives of Biochemistry and Biophysics, Volume 397, Issue 2, 2002, Pages 298-304, ISSN 0003-9861, Murtaza G, Khan AK, Rashid R, Muneer S, Hasan SMF, Chen J