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At the same time, overexpression of GLS1 (in particular, its GAC isoform) in the hippocampus, associated with severely impaired spatial and fear memory [41], is observed in MDD models [42], while GLS1 haploinsufficiency results in hippocampal hypometabolism and schizophrenia resilience phenotype [43], and, thus, has an antipsychotic-like effect [44]
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