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Other mechanisms by which this anti-FRα mAb suppresses cancer cell proliferation activity include sustained autophagy and disruption of the FRα and lyn kinase interaction which curtails intracellular growth signalling.10 Farletuzumab in combination with carboplatin/taxane, followed by single-agent farletuzumab maintenance was employed in a phase II study performed in patients with platinum-sensitive recurrent ovarian cancer.10 Single-agent farletuzumab was well-tolerated by the patients, and no additional toxicity was observed when the antibody was administered in combination with chemotherapy

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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Pavlova NN, Zhu J, Thompson CB