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Both carry the same intramolecular disulfide bridge, so the tyrosine substitution is the structural difference
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Food and Drug Administration (FDA) has approved amivantamab and hyaluronidase-lpuj (Rybrevant Faspro) for subcutaneous injection as an alternative for all approved indications of amivantamab-vmjw (Rybrevant), which is administered as an intravenous infusion to treat certain cases of non-small cell lung cancer (NSCLC)
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