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Such proteins can be modified in various ways, and reactivity is greatly enhanced for Cys whose thiol side chain is in the thiolate form, i.e., deprotonated at physiological pH (S − ): sulfenylation, nitrosylation, glutathionylation, persulfidation, and disulfide formation, responding to different oxidants (FIGURE 1)

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But hitting a larger vessel can produce a hematoma, a raised, tender collection of blood under the skin that takes longer to heal