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Under high-altitude hypoxia, alterations in gut microbial composition and function have been associated with intestinal barrier damage and may trigger a cascade of pathological reactions such as systemic inflammation, metabolic disorder, and oxidative stress

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The reduction in purine levels was associated with increased oxidative stress and endothelial dysfunction, both of which have been implicated in the pathophysiology of both ME/CFS and GWS (Furuhashi, 2020