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In the same study, in vitro assay using CYP2E1 inhibitors (dimethyl sulfoxide, dimethylformamide, hexane, and diallyl disulfide) show an inhibited N-nitrosodimethylamine (NDMA) activity that indicates that, like the liver, NDMA-activity in rat brains is catalyzed by CYP2E1 [46]

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In Phase 2 trials published in the New England Journal of Medicine (2023), participants lost an average of 17.5% of body weight at the highest dose over 24 weeks — outperforming tirzepatide and semaglutide in head-to-head data comparisons

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