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Interaction with inflammatory mediators Alterations in pro- and anti-inflammatory cytokines, including interleukin (IL)-6, IL-1β and tumour necrosis factor (TNF)–α, have been reported in populations with depression, and to a lesser extent, bipolar disorder and schizophrenia.16,17 These inflammatory cytokines are potential contributors to the underlying pathophysiology of these disorders
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Abstract Objective: Oxidative stress may be the unifying mechanism underlying the development of comorbidities in obesity
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