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UV radiation activates three key oxidative stress pathways: the epidermal growth factor receptor (EGFR)-mitogen-activated protein kinase (MAPK) cascade, nuclear factor kappa B (NF-κB)-mediated inflammation, and the nuclear factor erythroid 2-related factor 2(Nrf2)/antioxidant response element (ARE) axis
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Thus, different variations of the locus have been proposed in humans, including gene removal, inactivation, and duplication events [22]
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