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157 , 158 RSL3 can enhance tumor cell sensitivity to interferon-γ (IFN-γ), promote signal transducer and activator of transcription 1 (STAT1) phosphorylation and nuclear translocation, upregulate major histocompatibility complex class I (MHC-I) expression, and strengthen T cell-mediated cytotoxicity, thereby improving the therapeutic efficacy of αPD-L1 treatment