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On the molecular level, human microRNAs (miRNA) have also been identified as potential early biomarkers for indicating APAP-induced hepatotoxicity at a stage before alanine aminotransferases become elevated
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To recapitulate liver development, the differentiation of PCSs comprises three main steps: ‘PSCs to DE’, ‘DE to hepatic progenitor cells (HPCs)’, and ‘HPCs to HLCs’
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