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Our members will recall that the Pernicious Anaemia Society was the organisation which called for a specific B12 guideline to improve the diagnosis and treatment of Pernicious Anaemia

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Although many drugs are theoretically considered to be sufficiently lipophilic to pass through the barrier by passive transport, the presence of efflux transporters may significantly reduce tissue retention and efficacy due to their promiscuity for substrates and overlapping recognition of substrates that can be removed from the tissue microenvironment 28, 78–80