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As a member of the Cap ‘n’ Collar (CNC) transcription factor family, NRF2 exerts its function in the nucleus, by forming heterodimers with small musculoaponeurotic fibrosarcoma proteins (sMAFs), enabling NRF2 to bind to the enhancer region of the antioxidant response elements (AREs), which function as regulatory DNA sequences associated with the transcriptional activation of antioxidant enzymes and regulation of redox homeostasis (Katsuoka and Yamamoto, 2016)
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